Surface-Decorated Nanocarrier as a Targeted Drug Delivery Cargo to Folate Receptor-Overexpressing Cells for Enhancing Anti-cancer and Anti-inflammatory Activity
نویسندگان
چکیده
Aims: Folate receptor (FR) is overexpressed in most cancer cells and activated macrophages entailed rheumatoid arthritis (RA). The aim of the current study was fabrication FR-targeted nanocarrier loaded with methotrexate (MTX) to magnify its therapeutic efficacy limit toxicity.
 Methodology: Folic acid-chitosan (FA-CS) conjugate synthesized characterized. MTX poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared, optimized coated different concentrations FA-CS conjugate. selected NPs formulation (F10) evaluated via vitro vivo studies.
 Results: F10 had satisfactory encapsulation efficiency (76.2%), homogenous particle size (278.6 nm) positive zeta potential (34.0 mV) displayed biphasic drug release pattern pH media. Further characterization cinched incorporation polymeric matrix targeted nanocarrier. In cytotoxicity assay FR-positive FR-negative revealed improved anticancer effect cells, which absent compared free or uncoated (F2). showed appropriate storage stability at refrigerated temperature up 3 months. Moreover, oral administration treatment complete Freund’s adjuvant (CFA)-induced RA BALB/c mice conferred prodigious outcomes declined systemic toxicity conventional pure commercial tablets.
 Conclusion: fabricated could enhance activity FR-overexpressing be a promising novel approach for other inflammatory conditions associated macrophages.
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ژورنال
عنوان ژورنال: Journal of pharmaceutical research international
سال: 2023
ISSN: ['2456-9119']
DOI: https://doi.org/10.9734/jpri/2023/v35i187393